Key Organics

BIONET Building Blocks

• Over 220,000 Building Blocks including ex-stock subsets of Amines, Acids and many other functional groups.
• CoA and SDS available on request.
• Bulk quantities available.
• Purity guarantee.
• New compounds added every month

Fragment Libraries

2^nd Generation Premium Fragment library

• 1166 compounds with experimentally assured aqueous solubility in PBS buffer.
• Excludes fragments deemed to aggregate as determined by 1H NMR spectra
• 1H NMR pdf and raw data files provided for all compounds purchased, chemical shifts provided for all compounds in an excel file.
• Strictly meet Astex Rule of 3 including polar surface area ≤ 60 and number of atoms ≤ 16
• Includes 445 fragments found in approved drugs and >1100 sharing cores found in drugs
• Filtered to exclude promiscuous and reactive substructures

We also offer other curated fragment libraries:

• Covalent binder fragments
• Fluorine fragments
• Bromine fragments

Targeted protein Degradation (TBD)

Key Organics has a range of off-the-shelf products available for workers in the TPD field. We provide support for academic, biotech and pharma customers in this area through our growing range of catalogue ligands, linkers and tool compounds. Our bespoke fragment collection provides a rich resource for discovery of new ligands for both E3 ligases and target proteins of interest. We routinely undertake synthesis of bespoke or non-commercial compound(s) on either a custom fee-for-service (FFS) or contract (FTE) basis to support Hit Identification, Hit-to-Lead and Lead Optimisation activities for your discovery program.

Chemistry Services

Our team of highly experienced chemists have extensive synthetic organic chemistry capabilities and expertise that include the following areas:

• Multi-step complex custom synthesis
• Asymmetric synthesis
• Focused small library synthesis
• Vast hydrogenation/carbonylation expertise
• Heterocyclic chemistry
• Synthesis of literature standards
• Stable labelled compounds
• Pro-drug and linker synthesis
• Manufacturing impurities and metabolites
• Early process development
• Scale up lab to 25 litres
• We can operate under both FFS or FTE models to suit the client need