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Merck Life Science UK Limited, Gillingham (Dorset)

Stand: B92(Floor plan)
Analytical chemistry solutions
Chemical manufacturer
Filtration & separation

Non-Pyrophoric Organolithiums

Non-Pyrophoric Organolithiums: Easy to handle. Minimal risks.

Traditional organolithiums in hydrocarbon solvents pose significant fire and handling risks. Our breakthrough formulations use an innovative poly-α-olefin (PAO) solvent that eliminates pyrophoricity—validated by EPA's SW-846 Test Method 1050. These reagents are bench-stable for safer handling, offer extended shelf life versus conventional formulations, and maintain full reactivity across C–H lithiation, nucleophilic substitutions, SNAr, additions, and halogen exchange reactions. Compatible with KOtBu, TMEDA, and other common additives.

https://www.sigmaaldrich.com/GB/en/technical-documents/technical-article/chemistry-and-synthesis/organic-reaction-toolbox/novel-non-pyrophoric-t-n-butyllithium-formulations-chemical-synthesis
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