In the dynamic and hazardous realm of chemical processing, process safety is essential for safeguarding lives, protecting the environment, and ensuring operational integrity. This whitepaper explores the critical role of chemical reaction hazard modelling in advancing process safety. It highlights the integration of experimental data with theoretical insights, enabling accurate prediction and mitigation of complex chemical hazards. DEKRA’s science-driven approach leverages state-of-the-art computational techniques and real-world process understanding to develop robust models. A case study illustrates the application of kinetic modelling to address decomposition risks, underscoring the necessity of validated models in enhancing safety protocols and decision-making. The paper also delves into emerging technologies, such as artificial intelligence and digital twins, poised to revolutionise chemical hazard management. DEKRA’s commitment to innovation and safety excellence positions it as a trusted partner in navigating the complexities of industrial safety and driving progress in process safety management.