Beckman Coulter LS13320XR

The Beckman Coulter LS 13320 XR is a high-performance laser diffraction particle size analyser designed for fast, accurate measurement of particle size distributions across a wide analytical range. It is widely used in chemicals industries where particle size control directly impacts product performance and quality.

The system combines laser diffraction technology with Beckman Coulter’s proprietary PIDS (Polarization Intensity Differential Scattering), allowing enhanced resolution of fine particles and improved accuracy in complex or multi-modal distributions. It measures particles from approximately 10 nm to 3,500 µm, enabling a single platform to cover both nano- and macro-scale materials.

The measurement principle is based on analysing how a laser beam is scattered by particles in a sample. By combining multiple wavelengths and polarised light detection, the LS 13320 XR improves sensitivity in the submicron region and delivers highly detailed distribution profiles.

A key strength of the system is its flexible sample handling. It supports both wet and dry dispersion using interchangeable modules, including the Universal Liquid Module (ULM) and Dry Powder System (DPS). This makes it suitable for a wide variety of materials, from fragile agglomerates to stable suspensions and free-flowing powders.

The instrument is supported by advanced software that simplifies method development, data analysis, and reporting. It enables automated QC workflows, pass/fail criteria, and supports regulatory compliance such as 21 CFR Part 11, making it suitable for regulated environments including pharmaceutical manufacturing.

Operational efficiency is a major benefit of the LS 13320 XR. Automated alignment, self-check diagnostics, and rapid measurement cycles reduce downtime and improve reproducibility. Results are presented as full particle size distributions, typically by volume, with key parameters such as D10, D50, and D90 clearly reported for easy interpretation.